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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Telefone: +49 6151 72-0
Fax: +49 6151 72 2000
29 Julho 2010
carregando
| Nº de produto | Tamanho |
|---|
A cell-permeable antitumor alkaloid that acts as a potent inhibitor of topoisomerase II (IC50 = 3.3 µM). Restores functional wild-type p53 activity via inhibition of mutant p53 protein phosphorylation. Suppresses Cdk2 activity in a concentration-dependent manner. Also reported to inhibit telomerase activity in cultured pancreatic cells, possibly through inhibition of protein kinases. Binds to the aryl hydrocarbon receptor (AhR) in rat lung cytosol and inhibits aryl hydrocarbon hydroxylase (AHH) activity in rat hepatic microsomes.
| Informações sobre o produto | |||
|---|---|---|---|
| Form | Brown solid | ||
| Primary Target | topoisomerase 2 | ||
| Primary Target IC50 | 3.3 µM | ||
| Protect from Light | Sim | ||
| Hygrocopic | Sim | ||
| Packaged under inert gas | Sim | ||
| Cell permeable | Sim | ||
| Purity | ≥95% by HPLC | ||
| Fórmula Química | C17H14N2O · HCl | ||
| Número CAS | 52238-35-4 | ||
| Informação de estoque e transporte | |||
|---|---|---|---|
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<b>Hazardous Materials Attention:</b> Due to the nature of the Hazardous Materials in this shipment, additional shipping charges <i>may</i> be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges. |
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| Armazenagem | -20°C | ||
| Ship |
Ambient Temperature Only
Toxic & Carcinogenic / Teratogenic |
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| Informações de segurança | |||
|---|---|---|---|
| Frases S |
S: 36/37/39-45 |
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| Frases R |
R: 23/24/25-40 |
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