506149
p53 Activator III, RITA
NSC 652287, 2,5-bis-(5-Hydroxymethyl-2-thienyl)-furan, Reactivation of p53 and Induction of Tumor cell Apoptosis
Para informações, por favor, contate o nosso Serviço de Atendimento ao Cliente
Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Telefone: +49 6151 72-0
Fax: +49 6151 72 2000
31 Julho 2010
carregando
| Nº de produto | Tamanho |
|---|---|
| 506149-1MG | 1 mg |
A cell-permeable, p53-targeting, tricyclic thiophene derivative that displays antitumor properties. Blocks p53—MDM2 interaction and p53 ubiquitination and induces p53-dependent apoptosis in tumor cells expressing wild-type p53. Shown to restore the tumor suppressor function of p53 by inducing its accumulation in HCT116 colon carcinoma cells (~0.1 µM) and in p53-positive SCID mice xenografted with HCT116 cells (0.1, 1 or 10 mg/kg, ip) in vivo.
| Informações sobre o produto | |||
|---|---|---|---|
| Form | Crystalline solid | ||
| Protect from Light | Sim | ||
| Packaged under inert gas | Sim | ||
| Purity | ≥97% by HPLC | ||
| Fórmula Química | C14H12O3S2 | ||
| Número CAS | 213261-59-7 | ||
| Informação de estoque e transporte | |||
|---|---|---|---|
| Armazenagem | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Irritant |
||
