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Merck KGaA
Frankfurter Str. 250
64293 Darmstadt
Germany
Telefone: +49 6151 72-0
Fax: +49 6151 72 2000
31 Julho 2010
carregando
| Nº de produto | Tamanho |
|---|---|
| 506155-10MG | 10 mg |
A cell-permeable sulfonamide that blocks p53 interaction with Bcl-xL and Bcl-2 proteins and selectively inhibits p53 translocation to mitochondria without affecting the transactivation function of p53. Effectively protects against γ radiation-induced cell death in vitro and animal lethality in vivo. Because Pifithrin-μ targets only the mitochondrial branch of the p53 pathway without affecting the important transcriptional functions of p53, it is superior to Pifithrin-α (Cat. No. 506132) in in vivo studies. Shown to selectively interact with inducible HSP70 and disrupt its functions.
| Informações sobre o produto | |||
|---|---|---|---|
| Form | Off-white solid | ||
| Protect from Light | Sim | ||
| Packaged under inert gas | Sim | ||
| Purity | ≥95% by HPLC | ||
| Fórmula Química | C8H7NO2S | ||
| Número CAS | 64984-31-2 | ||
| Informação de estoque e transporte | |||
|---|---|---|---|
| Armazenagem | +2°C to +8°C | ||
| Ship |
Ambient Temperature Only
Standard Handling |
||
