Novidade : Signal Transduction Book

"Signal Transduction Book" é a mais nova ferramenta de pesquisa da Merck na área de Transdução de Sinal.
O livro aborda de uma forma clara e objetiva o Processo de Comunicação Celular, uma das áreas mas fascinantes da Biologia Moderna. Destina-se a toda Comunidade Científica, destacando as principais cascatas metabólicas, suas disfunções e o desenvolvimento de novas drogas para normalização desses processos.

A publicação é dividida da seguinte forma:

► 32 capítulos relatando diversos aspectos na área de transdução de sinal e suas disfunções.
► 3 capítulos escritos por cientistas renomeados;
► Literaturas e referências atuais;
► Diagramas e tabelas.

Regularmente, você receberá informativos técnicos sobre o livro. Aqueles que já foram anteriormente divulgados, já estão disponíveis para nova vsualização. Clique no título do boletim e confira as informações:

Boletim 1 - p53 and MDM2 Partners in Repair and Death

Boletim 2 - TGF-ß Signaling: Dual Role in Tumor Supression and Oncogenesis

E mais uma novidade... A Merck quer te presentear com este lançamento!
Envie um e-mail para paola.c.braga@merck.com.br e concorra ao sorteio mensal de um exemplar do ST Book!

Aqui, você tem a oportunidade de conhecer um pouco mais sobre nossos produtos. Veja abaixo a lista de produtos relacionados com a área de transdução de sinais.

p53 Activators

Product	Coments	Cat. No.	Size
p53 Activator, Cell-Permaeable	A cell-permeable peptide corresponding to the C-terminal amino acids 361 - 382 of p53. Binds mutant p53 and restores its growth suppressor functions in human tumor cells.	506131	500 µg
p53 Activator II, Cell-Permeable	A cell-permeable, proteolytically stable p53-activating peptide with antitumor properties.	506144	500 µg
p53 Activator III, RITA	A cell-permeable, p53-targeting, tricyclic thiophene derivative that blocks p53-MDM2 interaction and p53 ubiquitination. Induces p53-dependent apoptosis in tumor cells expressing wild-type p53.	506149	1 mg
PRIMA-1	A cell-permeable quinuclidinone analog that restores biochemical and biological function to mutant p53 and induces p53-dependent apoptosis in vitro and in vivo.	530050	10 mg
Tenovin-1	A cell-permeable activator of p53 that is shown to protect p53 from MDM2-mediated degradation,	580566	10 mg

p53 Inhibitors

Headline 01	Headline 02	Cat. No.	Size
Ellipticine, 9-Hydroxy-, Hydrochloride	A cell-permeable, potent inhibitor of topoisomerase II (IC50 = 3.3 μM). Restores functional wild-type p53 activity via inhibition of mutant p53 protein phosphorylation.	324680	10 mg
Pifithrin-α	A cell-permeable chemical inhibitor of p53. Reversibly inhibits p53-dependent transactivation of p53-reponsive genes and reversibly blocks p53-mediated apoptosis.	506132	5 mg 10 mg
Pifithrin-α, Cyclic-	A cell-permeable, very stable analog of Pifithrin (Cat. No	506134	10 mg
Pifithrin-α, p-Nitro	A cell-permeable p53 inhibitor that serves as the prodrug form of Pifithrin-α, p-Nitro, Cyclic (Cat. No. 506154)	506152	5 mg
Pifithrin-α, p-Nitro, Cyclic	A cell-permeable p53 inhibitor with 10-fold higher potency (ED₅₀=30 nM in protecting etoposide-induced cortical neuron death) and 50% longer half-life than Pifithrin-α (Cat. No. 506132).	506154	5 mg
Pifithrin-α	A cell-permeable blocker of p53 interaction with Bcl-2 and Bcl-2 proteins. Selectively inhibits p53 translocation to mitochondria withou affecting the transactivation function of p53. Targets only the mitochondrial p53 pathway withou affecting the important transcriptional functions of p53.	506155	10 mg

Antibodies for p53 Research

Product	Immunogen	Coments	Species Reactivity	Applications*	Cat. No.	Size
Anti-p53 (Ab-1) (Pantropic) Mouse mAb (PAb421)	Partially purified mouse p53 protein	Recognizes wild type and mutant mammalian p53.	Human, monkey, mouse, rabbit and rat	FC, FS, GS, IB, IF, IP	OP03	20 µg 100µg
Anti-p53 (Ab-1) (Pantropic) Mouse mAb (PAb421)	Partially purified mouse p53 protein	Recognizes wild type and mutant mammalian p53.	Human, monkey, mouse, rabbit and rat	FC, FS, GS, IB, IF, IP	OP03L	100µg
Anti-p53 (Ab-1) (Pantropic) Mouse mAb (PAb421)	Partially purified mouse p53 protein	Recognizes wild type and mutant mammalian p53.	Human, monkey, mouse, rabbit and rat	FC, FS, IF	OP03F	100 µg
Anti-p53 (Ab-2) (Pantropic) Mouse mAb (PAb1801)	Partially purified fusion p53 protein	Recognizes wild type and mutant p53 under non-denaturing conditions and both mutant and wild-type p53 under denaturing conditions.	Human	FS, GS, IB, IB, IP, PS	OP09	20 µg 100µg 200µg
Anti-p53 (Ab-3) (Mutant) Mouse mAb (PAb240)	Recombinant p53 (amino acids 14-389)protein fused to β-galactosidase	Recognizes wild type and mutant p53 under non-denaturing conditions and both mutant and wild-type p53 under denaturing conditions.	Bovine, chicken, hamster, human, mouse and rat	FC, FS, GS, IB, IF, IP, PS	OP29	20 µg 100µg 200µg
Anti-p53 (Ab-3) (Mutant) Mouse mAb (PAb240)	Recombinant p53 (amino acids 14-389)protein fused to β-galactosidase	Recognizes wild type and mutant p53 under non-denaturing conditions and both mutant and wild-type p53 under denaturing conditions.	Bovine, chicken, hamster, human, mouse and rat	FC, FS, GS, IB, IF, IP, PS	OP29L	100µg
Anti-p53 (Ab-4) (Wild type) Mouse mAb (PAb246)	BALB/c SVA31 E7 cells	Recognizes wild-type p53 in its native conformation. Does not recognize mutant or denatured p53.	Mouse and rat	IC IP, PS	OP32	100µg
Anti-p53 (Ab-4) (Wild type) Mouse mAb (PAb246)	BALB/c SVA31 E7 cells	Recognizes wild-type p53 in its native conformation. Does not recognize mutant or denatured p53.	Mouse and rat	IC, IP, PS	OP32L	100µg
Anti-p53 (Ab-5) (Wild type) Mouse mAb (PAb1620)	VLM mouse tumor cells	Recognizes wild-type p53 protein in its native conformation in Hs27 cells and breast carcinoma tissue. Does not recognize mutant or denatured p53.	Bovine, human, mouse, primate and rat	FS, IF, IP, PS	OP33	20 µg 100µg
Anti-p53 (Ab-6) (Pantropic) Mouse mAb (DO-1)	Recombinant human wild type p53	Recognizes wild-type and mutant p53 in A-431 cells and breast carcinoma tissue.	Feline and human	FS, GS, IB, IC, IP, PS	OP43	10 µg 20 µg 100µg
Anti-p53 (Ab-6) (Pantropic) Mouse mAb (DO-1)	Recombinant human wild type p53	Recognizes wild-type and mutant p53 in A-431 cells and breast carcinoma tissue.	Feline and human	FS, GS, IB, IC, IP, PS	OP43L	100µg
Anti-p53 (Ab-6) (Pantropic) Mouse mAb (DO-1) Agarose Conjugate	Recombinant human wild type p53	Recognizes wild-type and mutant p53 in A-431 cells and breast carcinoma tissue.	Feline and human	FS, GS, IB, IC, IP, PS	OP43A	0,5 ml
Anti-p53 (Ab-6) (Pantropic) Mouse mAb (DO-1) Agarose Conjugate	Recombinant human wild type p53	Recognizes wild-type and mutant p53 in A-431 cells.	Feline and human	FC, FS, IC, IF, PS	OP43F	100µg
Anti-p53 (Ab-7) (Pantropic) Sheep pAb	Recombinant human p53 protein	Recognizes wild-type and mutant p53 in A-431 and SVT2 cells and breast carcinoma tissue.	Human, mouse and rat	FS, IB, IF, IP, PS	PC35	1 each
Anti-p53 (Ab-11) (Pantropic) Mouse mAb (PAb 1802)	Recombinant human p53 protein	Recognizes wild-type p53 and mutant p53 in immunoblotting. Recognizes only the wild-type p53 in immunoprecipitation.	Human and mouse	IB, IP	OP104L	100µg
Anti-p53 (Ab-12) (Pantropic) Mouse mAb (DO-7)	Recombinant p53 expressed in E.coli	Recognizes wild-type p53 and mutant p53 in SKBR-3 and MDA-231 cells as well as in colon carcinoma tissue.	Bovine, human and monkey	FS, IB, IF, IP, PS	OP140	100µg
PhosphoDetect^TM Anti-p53 (pSer¹⁵) (Ab-3) Rabbit pAb	A phosphopeptide corresponding to amino acids surrounding the Ser¹⁵ of human p53	Recognizes p53 phosphorylated at Ser¹⁵ in PC 12 or HeLa cells treated with DNA damaging agents. Does not recognize unphosphorylated p53.	Human, mouse and rat	FFS, IB, IC, IP, PS	PC386	5µl 50µl
PhosphoDetect^TM Anti-p53 (pSer¹⁵) (Ab-6) Rabbit pAb	A phosphopeptide corresponding to amino acids 10-20 surrounding the Ser¹⁵ of human p53	Recognizes p53 phosphorylated at Ser¹⁵. Does not recognize unphosphorylated p53.	Human	IB, PS	PC461	25µl
PhosphoDetect^TM Anti-p53 (pSer²⁰) Rabbit pAb	A phosphopeptide corresponding to amino acids surrounding the Ser²⁰ of human p53	Recognizes p53 phosphorylated at Ser²⁰. Does not recognize unphosphorylated p53.	Human and mouse	IB, IC, IF, PS	DR1023	50µl
PhosphoDetect^TM Anti-p53 (pSer³⁹²) (Ab-4) Rabbit pAb	A phosphopeptide corresponding to amino acids surrounding the Ser³⁹² of human p53	Recognizes p53 phosphorylated at Ser³⁹². Does not recognize unphosphorylated p53.	Human and mouse	IB	PC387	50µl
PhosphoDetect^TM Anti-p53 (pSer³⁹²) Mouse mAb (9F4)	A phosphopeptide corresponding to amino acids surrounding the Ser³⁹² of human p53	Recognizes p53 phosphorylated at Ser³⁹². Does not recognize unphosphorylated p53.	Human and mouse	ELISA, IB	506133	100µl
PhosphoDetect^TM Anti-p53 (pSer⁴⁶) (Ab-4) Rabbit pAb	A phosphopeptide corresponding to amino acids surrounding the Ser⁴⁶ site of human p53	Recognizes p53 phosphorylated at Ser⁴⁶ in MCF7 cells treated with etoposide. Does not recognize unphosphorylated p53.	Human	IB, IC, IP	DR1024	50µl
Anti-p53 Binding Protein 1 (Ab-1) Rabbit pAb	Recombinant protein consisting of human 53BP1 fused to His•Tag^® sequence.	Recognizes the ~230 kDA 53BP1 protein in HeLa cell nuclear extract (Cat. No. WB64).	Human and mouse	IB, IF, IP	PC712	100µl
Anti-p53 Binding Protein 1 (Ab-1) Mouse pAb (BP13)	N-terminal human p53BP1/GST-fusion protein	Recognizes the ~230 kDA 53BP1 protein in HeLa nuclear extract (Cat. No. WB64) and HEK293 whole cell lysate.	Human	IB, IC, IP	DR1003	50µl

* ELISA: enzyme linked immunosorbent assay; FC: flow cytometry; FFS: free floating sections; FS: frozen sections; GS: gel shift; IB: immunobloting; IC: immunocytochemistry; IF: immunofluorescence; IP: immunoprecipitation; PS: paraffin sections

p53 Antibody Sampler Kit
Contains 20 µg of each of the following antibodies

Anti-p53 (Ab-1) (Pantropic) Mouse mAb (PAb421)        Cat. No. OP03
Anti-p53 (Ab-2) (Pantropic) Mouse mAb (PAb1801)      Cat. No. OP09
Anti-p53 (Ab-3) (Mutant) Mouse mAb (PAb240)            Cat. No. OP29
Anti-p53 (Ab-4) (Wild type) Mouse mAb (PAb246)        Cat. No. OP32
Anti-p53 (Ab-5) (Wild type) Mouse mAb (PAb1620)      Cat. No. OP33
Anti-p53 (Ab-6) (Pantropic) Mouse mAb (DO-1)            Cat. No. OP43

Cat. No. ASK07          1 Kit

p53 ELISA^PLUS (Autoantibody) Kit

Provided in a 96-well format. Plate is pre-coated
with recombinant human wild-type p53. The
detector antibody used is purified goat anti-human
polyclonal antibody conjugated with horseradish
peroxidase. Designed to measure circulating
antibodies to p53 in human serum samples. Assay
range: 0.16 - 1 antibody titer units

Cat. No. QIA53 1 Kit

p53 ELISA Kits

p53 ELISA Kit (Mutant Selective)

A 96-well ELISA kit for assay of mutant p53 protein in cell
extracts, serum, plasma, and other fluids. The antibodies
utilized in this kit react with an epitote exposed on human
and most mammalian mutant p53 proteins, but not on wild-type p53. Shows reactivity with mutant p53; also reactive with denatured wild-type p53.

Merck-BR:/imagem1.JPG

Cat. No. QIA03 1 Kit

p53 ELISA Kit (Pantropic)

A 96-well ELISA kit suitable for assay of mutant and wild-type p53 in human cell extracts, tissue extracts, conditioned media, serum and urine samples.
Assay range: 93.75 - 1500 pg/ml; Sensivity: 10 pg/ml

Merck-BR:/imagem2.JPG

Cat. No. QIA07 1 Kit

p53 Proteins and Related Peptides

p53, HisTag, Human, Recombinant, E. coli

Recombinant, human, wild-type, wild-type p53 fused at the N-terminus to a HisTag sequence and
expressed in E. coli. Useful in DNA binding assays and as a protein kinase substrate. Biological
activity: Typical DNA binding assays require 0.5 ng to 2 ng of p53 protein per assay. Purity: ≥80%
by SDS-PAGE.

Cat. No. 506165 10 µg

p53. Wild-Type, HisTag, Human, Recombinant, S. frugiperda

Human p53 expressed in a baculovirus expression system. Activity: 1 unit/ng protein. Bioogical
activity: Purity: ≥95% by SDS-PAGE.

Cat. No. 506147 5000 units

p53 (1-342, C-Terminal Deletion), HisTag, Human, Recombinant, S. frugiperda (p53 del 1-342)

A human mutant p53 (amino acids 1-342) with deletion of the C-terminal 51 amino acids, including
the entire basic domain and part of the tetramerization domain. Activity: 1 unit/ng protein.
Purity: ≥95% by SDS-APGE. M.W.40,000.

Cat. No. 506146 5000 units

p53, MDM-2 Binding Domain, N-Terminal 17-26, Cell-Permeable

(ETFSDLWKLLKKWKMRRNQFWVKVQRG)

Amino acids residues 17-26, derived, from the N-terminal MDM-2 binding domain of p53, and linked
to the Antennapedia leader sequence at the C-terminal. Directly binds to MDM-2 and induces non-
apoptotic cell-death (IC₅₀=40 µg/ml in TUC-3 cells) that is independent of p53 activation. Purity: >95%
by HPLC.

Cat. No. 506136 500 µg

TGF-ß Receptor I Kinase Inhibitors

TGF-ß RI Inhibitor ([3-(Pyridin-2-yl)-4-(4-quinonyl)]-1H-pyrazole)
A cell-permeable, potent, selective, ATP-competitive inhibitor of TGF-ß Receptor I kinase (IC50=51nM). Purity: ≥97% by HPLC. M.W. 272.3. Cat. No. 616451 5 mg

TGF-ß RI Kinase Inhibitor II (2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine)
A cell-permeable, potent, selective, and ATP-competitive inhibitor of TGF- type I receptor (ALK5; IC50 = 23 nM, 4 nM and 18 nM for ALK5 binding, ALK5 auto-phosphorylation and TGF- cellular assay in HepG2 cells, respectively). Purity: ≥95% by HPLC. M.W. 287.3. Cat. No. 616452 1 mg

TGF-ß RI Kinase Inhibitor II (2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine)

A cell-permeable, potent, selective, and ATP-competitive inhibitor of TGF- type I receptor (ALK5; IC50 = 23 nM, 4 nM and 18 nM for ALK5 binding, ALK5 auto-phosphorylation and TGF- cellular assay in HepG2 cells, respectively). Purity: ≥95% by HPLC. M.W. 287.3.

Cat. No. 616452 1 mg

TGF-ß RI Inhibitor III (2-(5-Benzo[1,3]dioxol-4-yl-2-tert-butyl-1H-imidazol-4-yl)-6-methylpyridine, HCl)
A cell-permeable, potent, selective, ATP-competitive, reversible inhibitor of activin receptor-like kinase 4 (IC50 = 129 nM), 5 (IC50 = 47 nM), and 7. Purity: ≥97% by HPLC. M.W. 371.9. Cat. No. 616453 2 mg

TGF-ß RI Inhibitor III (2-(5-Benzo[1,3]dioxol-4-yl-2-tert-butyl-1H-imidazol-4-yl)-6-methylpyridine, HCl)

A cell-permeable, potent, selective, ATP-competitive, reversible inhibitor of activin receptor-like kinase 4 (IC50 = 129 nM), 5 (IC50 = 47 nM), and 7. Purity: ≥97% by HPLC. M.W. 371.9.

Cat. No. 616453 2 mg

TGF-ß RI Inhibitor IV (3-(6-Methylpyridin-2-yl)-4-(4-quinolyl)-1-phenylthiocarbamoyl-1H-pyrazole)
A cell-permeable, selective inhibitor of ALK-4/5/7-mediated (IC50 = 45, 12, and 7.5 nM, respectively) signaling in Mv1Lu R4-2 transfectants expressing TGF- Receptor I. Purity: ≥98% by HPLC. M.W. 421.5. Cat. No. 616454 2 mg

TGF-ß RI Inhibitor IV (3-(6-Methylpyridin-2-yl)-4-(4-quinolyl)-1-phenylthiocarbamoyl-1H-pyrazole)

A cell-permeable, selective inhibitor of ALK-4/5/7-mediated (IC50 = 45, 12, and 7.5 nM, respectively) signaling in Mv1Lu R4-2 transfectants expressing TGF- Receptor I. Purity: ≥98% by HPLC. M.W. 421.5.

Cat. No. 616454 2 mg

TGF-ß RI Inhibitor V (2-(5-Chloro-2-fluorophenyl)pteridin-4-yl)pyridin-4-yl amine)
A cell-permeable, potent, selective, reversible inhibitor of TGF- RI/ALK5 kinase (EC50 = 48 nM). Purity: ≥97% by HPLC. M.W. 352.8. Cat. No. 616456 2 mg

TGF-ß RI Inhibitor V (2-(5-Chloro-2-fluorophenyl)pteridin-4-yl)pyridin-4-yl amine)

A cell-permeable, potent, selective, reversible inhibitor of TGF- RI/ALK5 kinase (EC50 = 48 nM). Purity: ≥97% by HPLC. M.W. 352.8.

Cat. No. 616456 2 mg

New!

TGF- RI Kinase Inhibitor VII (1-(2-((6,7-Dimethoxy-4-quinolyl)oxy)-(4,5-dimethylphenyl)-1-ethanone)
A cell-permeable, potent, ATP-competitive inhibitor of ALK5/TGF- Receptor I kinase activity (IC50 = 0.63 µM). Blocks TGF--induced Smad2 phosphorylation and Smad2/3 transcription activity (IC50 = 0.5 and 0.37 µM, respectively) in human lung cancer epithelial cell line A549.

Cat. No. 616458 5 mg

TGF-ß Family Proteins

Product	Coments	Cat. No.	Size
Activin A, Human, Recombinant, CHO, Cells	Recombinant, human activin A (disulfide-linked homodimer of two 116-amino acid residue ßA subnits) expressed in CHO cells. Inhibits endogenous IL-6 production. Biological activity: ED₅₀=0.5-2.0 ng/ml	114700	5 µg
TGF-ß1, Human Platelets	Native TGF-ß1 that is shown to promote apoptosis in resting human B lymphocytes, glioma cells, and trigeminal neurinomal cells. Biological activity: ED₅₀=40-10 pg/ml	616450	1 µg
TGF-ß1, Human, Recombinant, CHO Cell Line	Recombinant, human TGF-ß1 expressed in CHO cells. Biological activity: ED₅₀=0.04-0.1 ng/ml	616455	2 µg
TGF-ß1, Porcine Platelets	Native TGF-ß1 from porcine platelets. Biological activity: ED₅₀=0.1-0.2 ng/ml	616460	1 µg
TGF-ß2, Human, Recombinant, E. coli	A full length, recombinant, human TGF-ß2 that is reactive in many cell type. Biological activity: ED₅₀=0.1-0.3 ng/ml	PF017	1 µg
TGF-ß3, Human, Recombinant, S. frugiperda	Recombinant, human TGF-ß3 expressed in S. frugiperda insect cells. Biological activity: EC₅₀=0.01-0.03 ng/ml	PF073	2 µg

Other Related Proteins

Smurf2 Ligating Enzyme, Human, Recombinant, S. frugiperda

Recombinant, human Smurf2 expressed in S. frugiperda insect cells using a baculovirus expression system. Smurf2 is an E3 ubiquitin ligase with 83% homology to Smurf1. Smurf2 is known to be constitutively associated with Smad7. Purity: ≥98% by SDS-PAGE.

Cat. No. 662079 10 µg

SMAD3, GST-Fusion, Human, Recombinant, E. coli

Full-length, recombinant, human SMAD3 fused at the N-terminus to GST and expressed in E. coli. SMAD3 is a receptor-associated SMAD phosphorylated by TGF-ß 1R kinase. Purity: ≥90% by SDS-PAGE.

Cat. No. 566418 50 µg

Antibodies for TGF-ß Signaling Pathways

Product	Coments	Cat. No.	Size
Anti-Smad1 Rabbit pAb	Polyclonal, immunoaffinity purified lgG. Recognizes the ~60kDa human Smad1 protein. IB	566416	100 µg
PhosphoDetect^TM Anti-Smad1 (pSer^463/465) Rabbit pAb	Polyclonal, protein A purified lgG. Recognizes the ~65 kDa Smad1 protein phosphorylated at Ser^463/465 in human and mouse. IB	566411	50 µg
PhosphoDetect^TM Anti-Smad2 (pSer^465/467) Rabbit pAb	Polyclonal lgG, protein A and immunoaffinity purified. Recognizes the ~58 kDa Smad2 protein phosphorylated at Ser^465/467. Reacts with human, mink and mouse. IB	566415	50 µg
Anti-Smad3 (206-220) Rabbit pAb	Polyclonal lgG, protein A purified. Recognizes the ~50 kDa Smad3 protein in human, mouse and rat. IB	566414	50 µg
PhosphoDetect^TM Anti-Smad (pSer^423/425) / Smad 1 (pSer^463/465) Rabbit pAb	Polyclonal lgG, protein, A and immunoaffinity purified. Recognizes the ~58 kDa Smad3 protein phosphorylated at Ser433 and Ser435 in TGF-ß-treated HeLa cells and PC3 cells. IB, IC	PK1012	50 µg
Anti-Smad5 Rabbit pAb	Polyclonal lgG, protein A and immunoaffinity purified. Recognizes the ~60kDa Smad5 protein in SK-N-M, cos, and PC12 cells. Reacts with human, monkey, mouse and rat. IB	ST1104	50 µg
Anti-Sp1 (520-534) Rabbit pAb	Polyclonal lgG, immunoaffinity purified. Recognizes the ~105 kDa Sp1 protein in HeLa and K562 nuclear cells extracts. Reacts with human. ELISA, IB	PC701	100 µg
Anti-TGF-ß1 (Ab-1) Mouse mAb (9016.2)	Monoclonal lgG₁, purified. This antibody neutralizes the biological activities of TGF-ß1 and TGF-ß1.2. ELISA, IB, NT	GF33L	100 µg
ANTI-tgf-ß3 (Ab-1) Mouse mAb (236-5.2)	Monoclonal lgG₁, purified. Recognizes TGF-ß2 and TGF-ß3 in umbilical cord cells. Does not cross-react with TGF-ß1. Reacts with human, mouse and rat. FS, IB, IP, PS	GF16	200 µg

* ELISA: enzyme-linked immunosorbent assay; FS: frozen sections; IB: immunoblotting; IC: immunocytochemistry; IP: immunoprecipitation; NT: neutralization; PS: paraffin sections

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